Railroad dominance, the birth of Virginia Tech, and the opening of Hotel Roanoke paved the way for the region from 1875-1900.

Photos are courtesy of The Roanoke Times archives, Associated Press, via the Lacks family and the Henrietta Lacks Foundation; Floyd County Historical Society; Historical Photograph Collection, Special Collections, University Libraries, Virginia Tech; Roanoke Regional Chamber of Commerce; Gregory Rosenthal, Roanoke College; Virginia Military Institute Archives; Jerry Spangler.

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